Characterization of the Blood Brain Barrier in Pediatric Central Nervous System Neoplasms
نویسندگان
چکیده
منابع مشابه
Characterization of the blood brain barrier in pediatric central nervous system neoplasms
OBJECTIVE The normal blood-brain barrier (BBB) is composed of tight junctions between endothelial cells and surrounding astrocyte foot processes. Breakdown of the physiological astrocyte-endothelial cell relationship occurs in adult metastatic and primary brain tumors. However, the astrocyte-endothelial cell relationship has not been studied in pediatric tumors. MATERIALS AND METHODS Utilizin...
متن کاملCentral nervous system diseases and the role of the blood-brain barrier in their treatment
The Neurodegenerative diseases, cancer and infections of the brain are becoming more prevalent in society as population become older. Nowadays, these diseases represent a major medical challenge, so neuroprotective therapeutics have the potential to play a key role in managing this growing global burden of long-term neurological care. Despite major advances in neuroscience, treatment for these ...
متن کاملThe blood-brain barrier and its role in immune privilege in the central nervous system.
The blood-brain barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), strictly regulating the entry of many substances and blood borne cells into the nervous tissue. Increased understanding of how the unique microenvironment in the CNS influences the BBB is crucial for developing novel therapeutic approaches to CNS diseases. In this review, we...
متن کاملImmunologic privilege in the central nervous system and the blood-brain barrier.
The brain is in many ways an immunologically and pharmacologically privileged site. The blood-brain barrier (BBB) of the cerebrovascular endothelium and its participation in the complex structure of the neurovascular unit (NVU) restrict access of immune cells and immune mediators to the central nervous system (CNS). In pathologic conditions, very well-organized immunologic responses can develop...
متن کاملADENOSINE IN THE CENTRAL NERVOUS SYSTEM
Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Interdisciplinary Histopathology
سال: 2016
ISSN: 2146-8362
DOI: 10.5455/jihp.20160623053540